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10.1016/j.bbrc.2007.08.196 Biochem

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Patients have reported patchy skin color (where different areas of the skin have different tones) and premature graying of hair due to the significant reduction of melanin

10.2 Mechanism and molecular target of cysteine and methionine The metabolism of homocysteine involves two pathways, i.e., reverse transsulfuration and transmethylation pathway, which results in its conversion into cysteine and methionine, respectively (Figure 1)

GSH is of paramount importance for the appropriate function of the immune system in general and particularly lymphocytes since low GSH levels inhibit T lymphocytes proliferation and subsequently disturbs the immune response (Hamilos et al., 1989