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Additionally, glial cell activation synergistically contributes to neurodegeneration

MK-801 is the most effective NMDA inhibitor but unfortunately is not clinically safe (see Chapters 13 and 20 )

Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed using the StepOne Real-Time PCR System (Thermo Fisher Scientific, Waltham, MA) and THUNDERBIRD SYBR qPCR Mix (Toyobo)

With the aid of X-ray crystallography and site-directed mutagenesis techniques, the roles of GST active site amino acid residues were identified and evaluated [62, 81]