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Tretinoin is an FDA-approved retinoid with the strongest clinical evidence for photoaging

It plays an important role in protecting cells from oxidative stress caused by pollution, UV exposure, lifestyle factors, and normal metabolic processes

The Dietary Approaches to Stop Hypertension (DASH) diet, which highlights high consumption of fruits, vegetables, whole grains, low-fat dairy products, and reduced sodium intake, has also been linked to a slower cognitive decline [50]

Clinically, metformin is well tolerated, with gastrointestinal symptoms and vitamin B12 deficiency representing the most common adverse effects (Top et al., 2022)

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