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doi: 10.1124/mol.111.076422 53 LiuT.ZhongS.LiaoX.ChenJ.HeT.LaiS.et al

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45,46 Increasingly, more studies have shown that G6PD activity is increased in several types of cancers, including bladder, breast, prostate, gastric cancers compared with normal tissues, and the high expression of G6PD predicts poor clinical outcome in various cancer patients and plays critical roles in tumorigenesis and chemoresistance

For patients dealing with fatigue, stress, or nutrient depletion, that distinction can be meaningful

While the more obvious route would be directly suppressing TNF, that might not be a good idea because of its important roles in fighting infections and other invaders, which is already a concern for current treatments, they say