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Journal of Medical Genetics, 45 (4), 233238

Particularly, in fibroblast and neuronal cells from derived from of PKANs patients, lipid peroxidation and alteration of oxidative status (increased ROS production), mitochondrial impairment (including defects in mitochondrial respiration and electrophysiological properties) and premature cell death have been detected [9, 18]

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The rapid apoptosis of fat cells and the breakdown of vascular tissue release significant cellular debris into the bloodstream, which the kidneys must filter