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While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10

Additionally, formononetin primarily promotes ferroptosis by modulating the activity of the xCT/GSH/GPX4 axis, which is mediated by the downregulation of SREBP1 expression

Todorova V, Blokland A

The synthesis of glycosaminoglycans promotes blood vessel growth