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If toxins are mobilized faster than the liver and bowels can eliminate them, they flood the bloodstream, triggering a massive inflammatory immune response

A few considerations: Niacin flush : High-dose niacin (not the same as NMN/NR) causes flushing

Light rubbing is acceptable

Nephrol Dial Transplant 20(12):26362645 Sugiyama M, Kawahara-Miki R, Kawana H, Shirasuna K, Kuwayama T, Iwata H (2015) Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows

Both compounds would benefit significantly from independent replication, chronic safety studies, and -- if warranted by safety data -- carefully designed early human studies