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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

Further, it gets converted into cytotoxic metabolite, fluorodeoxyuridine monophosphate (F-dUMP)

Methods 153, 99105 (1992)

Dihexa demonstrates poor oral bioavailability due to first-pass hepatic metabolism and peptide bond degradation in gastric acid published oral doses require 1050 times the subcutaneous dose to achieve equivalent plasma levels

Studies of mouse lifespan must take into account gender differences