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Generally, the NSAIDs-induced sphincter failure may be quite prominent, at least in the range of that induced mechanically by prolonged stretch, after tube insertion into the lower esophageal and/or pyloric sphincter and sphincter failure in esophagitis rats (30-32), surgically by anastomosis and fistulas creation (26, 27, 29), or chemically, by huge potassium-overdose application (28)

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Thus, small alcohols like methanol (CH 3 OH), ethanol (CH 3 CH 2 OH), and propan-1-ol (CH 3 CH 2 CH 2 OH) are infinitely soluble in water, as shown in Table 2-6

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