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[24] Remember: Children are strong

Ethics declarations The authors declare no competing interests

RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

Results obtained in rats castrated before puberty (3 weeks of age) were taken as supporting this hypothesis, since the penile AR concentration remained at immature levels at 7 and 13 weeks after castration, but decreased to the respective age levels if DHT was administered immediately after castration.2 However, it should be noted that the total penile AR content in the castrated animal reaching adulthood remained as low as in the adult animal because the penis grew very little in that period

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