Its unique structure allows it to act as a powerful antioxidant, protecting cells from damage caused by free radicals, which are unstable molecules that can lead to oxidative stress
LPS and PGN are prototypical classes of pathogen-associated molecular patterns (PAMPs) that are recognized by TLRs, leading to the activation of proinflammatory signaling pathways (Kawai and Akira, 2011)
Additionally, DJ-1 -deficient embryonic cortical neurons show increased sensitivity to oxidative damage
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In SJL mice with EAE, a 7-day oral antibiotic regimen (ampicillin, vancomycin, neomycin, metronidazole) before disease induction led to amelioration of the disease through an accumulation of Tregs in the peripheral lymph nodes (Ochoa-Repraz et al., 2009)