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Inhibiting NNMT has been proposed as a therapeutic strategy for metabolic disease

By promoting a more robust metabolic function, this promising compound could potentially address age-related changes in body composition and metabolism, such as increased fat tissue as fat cells grow larger

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They might have decreased kidney function, drug interactions, and more malabsorption issues

Institutional research settings that track NAD+ levels and methylnicotinamide excretion often find individual dose-response variability of 3040%, meaning the 'right' dose for one subject may be subtherapeutic or excessive for another