Establish baseline measurements and apply randomization and blinding where possible to minimize bias
In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
Stefanescu R, Tero-Vescan A, Negroiu A, Aurica E, Vari CE
Alveolar bone resorption was also calculated under the furcation area
Calcitonin gene-related peptide augments parasympathetic contraction of rabbit tracheal smooth muscle in vitro