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According to the Global Burden of Disease Study 2021, ALS prevalence has increased by nearly 68% between 1990 and 2021, with incidence rising by 74.5% and associated DALYs by 105.5% [1]

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It has been reported that STAT3 can directly bind to NF-B and facilitate its nuclear translocation and target gene expression, suggesting that STAT3 is involved in the constitutive activation of NF-B (39)