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doi: 10.1038/s41598-019-53174-6 219 LukiwWJSurjyadiptaBDuaPAlexandrovPN

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(2020) discovered that STIP1 homology and U-box containing protein 1 is the E3 ligase most likely to participate in IRP2 ubiquitin, but whether another significant ubiquitinase of IRP2, F-box and Leucine Rich Repeat Protein 5, is involved in this process has not been answered positively by the researchers and needs further investigation