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Participants were excluded if they had significant medical histories, abnormal lab results, or conditions affecting alcohol metabolism or absorption of the investigational product

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Future studies could utilize patient-derived human pluripotent stem cells and differentiate them into T cells to decipher the mechanisms that trigger the population shift from nave T cells to other cell types, including CD8+TCF1 high cells, and determine whether these autoreactive T cells can lead to the destruction of cells using human in vitro models

have investigated the biological activities of 480 molecules, of which 53 molecules are cytotoxic to Candida albicans and 16 molecules can inhibit hyphal transformation without affecting germination and multiplication

Acknowledgements We acknowledge the AAV Core Facility of Academia Sinica for generating recombinant AAV (Grant AS-CFII112-204)