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In 1963, Froesch et al (5) discovered the presence of a certain active substance in serum that could not be completely inhibited by insulin antibodies

As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization

OxS has been proposed as one of the major contributing factors in the destruction of the GI tract, and this is associated with some of the characteristic features of CD, e.g

Schuck PF, Tonin A, da Costa FG, Rosa RB, Latini A, Balestro F, et al

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