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This leads to the immediate release of cytokines and chemokines, which recruit and activate immune cells such as neutrophils and macrophages to eliminate pathogens ( 3 The origin of trained immunity This phenomenon of non-specific immune memory was first observed in plants and invertebrates, both of which, as evolutionarily ancient organisms, lack adaptive immune systems and rely solely on innate immune mechanisms to combat infections ( Streptococcus pneumoniae or Beauveria bassiana ( pasteuria ramosa to their offspring via maternal transmission ( Candida albicans (PCA-2) into Rag1 / mice lacking mature T and B cells, these mice exhibited protection against subsequent lethal systemic C

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