In most cases, these symptoms are mild to moderate and improve over time, but they can be severe enough for some patients to discontinue treatment (semaglutide STEP 1 trial results)
Researchers using DEXA scans or waist circumference measurements often see disproportionate reductions in trunk fat compared to peripheral fat during this phase
According to the Office of Dietary Supplements, the following people are most at risk for thiamine deficiency: Older adults Those dependent on alcohol People with HIV/AIDS People with diabetes Those who have had bariatric surgery Mount Sinai: "Thiamin" National Institutes of Health Office of Dietary Supplements: "Thiamin" Mayo Clinic Laboratories: "Thiamine (Vitamin B1), Whole Blood" America's Poison Centers: "Get online poison help now" PubChem: "Thiamine Hydrochloride - Safety and Hazards" BMJ Case Reports: "Anaphylactic Shock and Cardiac Arrest Caused by Thiamine Infusion" MedlinePlus: Thiamine (Vitamin B1) Lynn Grieger, RDN, CDCES Medical Reviewer Lynn Grieger is a registered dietitian-nutritionist, certified diabetes care and education specialist, certified personal trainer, and certified health and wellness coach
GLP-1 RAs have high glucose-lowering efficacy, but with variation within the drug class
This means that high serum B12 levels can persist for some time after large supplemental doses
