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In Th1 cells, IL-18, particularly in synergy with IL-12 (74), enhanced the production of interferon (IFN)-, which, as a regulator, acts on the overactivation-associated receptor SLAMF7 on RA macrophages to boost macrophage activation and amplify inflammation (75)

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If participants did not reach the threshold in the initial 2 seconds or if the force level fell below the maintenance threshold during the 3 seconds maintenance period, the trial was considered failed and visualized by a red cross occurring on the screen

Interferon-gamma is a relevant signaling molecule of the immune system and supports combating viral infections through T lymphocyte, macrophage, and natural killer cell activation

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