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Inset: Concentration-response curves of the cCSE prepared from 20 or 40 cigarettes with a change in scale of concentrations on x axis

Perhaps decades ago there was some confusion about how dangerous it is, but today, it is clear. The conventional wisdom followed the Igres Moshe (Rabbi Moses Feinstein) who, in a responsum, stated it was permitted, but inadvisable

Its impact on CYP2E1, CYP2A1/2A2, and CYP2B1/2B2 has been demonstrated within the central nervous system (Zevin and Benowitz, 1999)

A doseresponse relationship with the amount of smoking has also been demonstrated

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