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While these interactions do not establish direct causality, they provide integrative evidence linking metabolomic alterations to gene networks previously implicated in neurodevelopmental and metabolic regulation
Overlapping conditions and diagnosis: Many other conditions have mast cell activation as a component, including idiopathic abdominal pain, GERD (heartburn), chronic urticaria, fibromyalgia, atypical drug and insect bite reactions, allergies, chronic sinusitis, pharyngitis and vocal tension, dermatographism, chronic headaches, interstitial cystitis, and atrial fibrillation.[ref] Additionally, some researchers point out the growing evidence of mast cell involvement in several different autoimmune diseases, including MS, type 1 diabetes, and rheumatoid arthritis.[ref] Lets dig into some of these in more depth, exploring how they relate to mast cell activation
Translocation of microorganisms into the intercellular compartments and further into the deeper tissue layers causes microinflammation
It has not been evaluated by the FDA for safety or efficacy in humans
