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The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation (Song et al., 2025)

Given that FOXO4 is a transcription factor, this nuclear translocation suggests increased transcriptional activity

Kinetics in humans and homeostasis Compartmentalization Different forms of folate have different abilities to be transported through the biological membranes, which results in compartmentalization of folate between extracellular space, cytosol, and mitochondria, with smaller folate amounts located in the nucleus 875

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