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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Inject once daily subcutaneously

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Cagrilintide dosing protocols Standard titration (monotherapy): Weeks 1-4: 0.6mg weekly Weeks 5-8: 1.2mg weekly Weeks 9-12: 1.8mg weekly Week 13+: 2.4mg weekly (maintenance) Why slow titration critical: Reduces GI side effects dramatically Allows body adaptation to gastric slowing Better long-term adherence Proven in clinical trials CagriSema dosing: Semaglutide: 0.25mg 2.4mg over 16 weeks Cagrilintide: 0.6mg 2.4mg over 12 weeks Both at maximum by week 17 Continue indefinitely for maintenance Administration: Subcutaneous injection Weekly dosing (same day each week) Abdomen, thigh, or upper arm Rotate sites See our cagrilintide dosing guide for complete protocols