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Only clinical study designs (S)randomised controlled trials (RCTs), non-RCTs, cohort, or case-control studieswere included

According to the Mayo Clinic, parenteral vitamin B12 therapy is clinically indicated for treating deficiency caused by pernicious anemia, gastrointestinal disorders such as tropical sprue, and conditions resulting in malabsorption like pancreatic insufficiency

Subsequent investigations examined genes functionally linked to OA by assessing promoter methylation and mRNA expression in cartilage tissue, primary chondrocytes, and chondrocyte cell lines

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Venkateshappa C, Harish G, Mahadevan A, Bharath MS, Shankar SK (2012) Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimers disease