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707 Besides, metformin protects against gluco- and lipotoxicity-induced osteoblast apoptosis and reverses T2DM-associated deterioration in skeletal health, whereas depletion of PGC-1 abolishes this protective effect
Furthermore, because MCI develops years before dementia onset and can affect individuals younger than 65, there are likely more than 5 to 7 million people of any age with MCI due to Alzheimer's disease, and thus the 10 to 12 million estimate could be even higher if we consider Americans of all ages, not just those 65 or older
Int J Mol Sci 20(9)
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