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Genetic differences can explain why some people may develop cancer or become addicted much quicker to nicotine than others

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For instance, the carbon monoxide present in tobacco can deprive the heart of oxygen needed to pump blood

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Tobacco smoke has a suppressive effect on the protective functions of immunocyte and adaptive immune mechanisms, and had a direct effect on microbial pathogens to enhance the probability of infectious disease, specifically promoting microbial virulence and antibiotic resistance [18, 53]