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CONCLUSIONS Based on untargeted metabolomics and bioinformatics analyses, 1150 metabolites were identified to be differentially expressed between the HN and LN groups, such as cotinine, NNAL-N-glucuronide, and 11-dehydrothromboxane-B2

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Its activity is controlled by signal pathways and cell conditions, which affect its interaction with various binding partners, thereby regulating Sp1-dependent transcription [22, 23]