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Timely filter core replacement is key to maintaining the function of the filter holder at the highest level

"The Mystery Zone" Transference 24

We do not consider that limiting attention to studies of 100 cases or more is of particular importance as results from smaller studies would contribute little weight to the overall meta-analyses

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However, the route, speed and amount of nicotine absorption (and subsequent nicotine levels in plasma) are important determinants of the efficacy of ECs to serve as smoking substitutes and of any concerns about nicotine overdose or intoxication