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Histones are well known to undergo a variety of post-translational modifications, namely phosphorylation, acetylation, methylation, and ubiquitination ( Figure 1 )

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While angiogenesis in the adult brain is classically considered quiescent under physiological conditions, mounting evidence from pathological contextssuch as stroke, trauma, glioma, and multiple sclerosisdemonstrates that angiogenic reactivation can occur in response to stress or injury (Thomsen et al