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The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery

In addition to increasing the generation of superoxide anions, hydrogen peroxide, and other peroxides, homocysteine may thus decrease the cellular ability to detoxify peroxides, especially hydrogen peroxide

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Cell Microbiol (2015) 17:13145.10.1111/cmi.12343 49 ImaiYKubaKNeelyGGYaghubian-MalhamiRPerkmannTVan LooGet alIdentification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury

The researchers also examined the serotonin levels in the blood plasma platelets since serotonin is involved in regulating sleep and wakefulness