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Li, R., Li, J

A key player in the formation of invasive breast tumors is TREX1, which mediates confinement-induced DNA damage, collagen degradation, and the acquisition of a hybrid epithelial-mesenchymal phenotype [195]

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females