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But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

Category 2 means the substance does not meet the criteria for compounding under sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act

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Any excess is typically excreted in the urine, lowering the risk of toxicity

Folate and other one-carbon metabolism-related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort