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The microchannels increase skin permeation more than twentyfold compared with intact skin

Samples were diluted 100-fold, applied to copper grids, and stained using uranyl acetate at a concentration of 2% w/v

These results far exceed the Phase 2 trial outcomes and position retatrutide as potentially the most effective weight loss medication in development

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Oganesyan V, Peng L, Bee JS, Li J, Perry SR, Comer F, Xu L, Cook K, Senthil K, Clarke L, Rosenthal K, Gao C, Damschroder M, Wu H, DallAcqua W (2018) Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody