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Linden A, Hansson L, Andersson A, Palmqvist M, Arvidsson P, Lofdahl CG, Larsson P, Lotvall J

Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used

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If density declines significantly, interventions include calcium and vitamin D optimization, weight-bearing exercise, and sometimes pharmacologic therapy

A pre-specified cardiovascular meta-analysis from SURPASS programme studies showed that there is no excess cardiovascular risk with tirzepatide use [51], however the ongoing SURPASS-CVOT (NCT04255433) will provide evidence on the definitive impact of tirzepatide on cardiovascular disease in people with T2D (Figure 4)