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Retinoids temporarily disrupt the stratum corneum barrier, which is why clinicians recommend against layering other actives early in the process

This molecule is found in nearly every cell of the human body

Clin Drug Invest 1996;11(2):90-96

Cancer cells and normal cells potentially use different food sources, Harris explained, and we discovered how cancer cells, specifically, break down this antioxidant and use it as fuel. The new role for glutathione is notable, Harris said, because until now, most scientists who study glutathione have focused on the way it can prevent or repair cell damage, rather than its ability to feed cancer cells

It means that you are nowhere near the saturation point, or that there are natural economies of scale in the channel, where performance increases as you reach the top