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The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]
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Dogs are primarily used in regulatory research, also known as toxicology or safety testing
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Add some more stress and anxiety and they stop being able to cope which is why they will chain smoke in stressful situations
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