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however, meta-analyses of RCTs, 18,19 observational studies, 2022 and a large RCT including participants both with and without mental illness 23 have not supported a causal link

Clarifying the stages at which these pathways contribute to the inflammatory phenotype and identifying the cell types orchestrating this inflammasome-independent response are crucial areas for further investigation

This eliminates unexpected issues

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This is in contrast to the significant increase in the proportion of light smoking and the decrease in heavy smoking that occurred between 2016 and 2019