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Eat your veggies: One study found that people who carried the CYP1A1*2 variant had a greater reduction in colon cancer risk with a diet high in polyphenols (found in veggies and fruit) than those without the variant.[ref] Grapefruit: Grapefruit juice inhibits CYP1A1, which is something to be aware of if you consume a lot of grapefruit.[ref] Supplements and CYP1A1: Natural supplements can also affect CYP1A1 expression