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Levels in the low-normal range, between 200 and 300, may warrant supplementation even without overt symptoms, particularly in patients with risk factors for deficiency

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Unlike retinoids, GHK-Cu is not known to cause barrier disruption and carries no standard photosensitization warning

For this reason, DSIP is most often studied in the context of sleep architecture, stress regulation, and neuroendocrine balance rather than as a pure sleep-onset agent

However, in vivo studies primarily in humans are needed to confirm these promising preclinical findings