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All 1,329 pregnant women (79.8% white) smoked combustible cigarettes within the 3 months before pregnancy and used e-cigarettes before pregnancy (n = 890), initiated e-cigarette use during pregnancy (n = 67) or used nicotine replacement therapy during pregnancy (n = 372)

Spirometry to confirm air flow limitation: FEV1/FVC 300 cells/microL, then start ICS

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Dysbiosis of intestinal microbiota closely associates with the skin diseases, such as acne, psoriasis and atopic dermatitis (van Splunter et al., 2020)