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Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues

As oligodendrocyte progenitor cells (OPCs) were detected in chronic lesions [5,6], it appears that premyelinating OLs fail to differentiate and ensheath the axon with myelin in chronic MS

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This reliance on a single enzyme for both GSSG and Trx reduction suggests that the parasite's redox systems are subject to a bottleneck dependence on TGR