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In zebrafish, acute toxicity of PE MPs indicated neurotoxicity, disruption of the aryl hydrocarbon receptor pathways and oogenesis [16]

It is therefore plausible that the upregulation of Bmal1 and the modified activation of the negative feedback loop, which takes place in all brain areas, acts as a counterbalancing mechanism to the neurodegenerative effect

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Similarly, total oxidative status (TOS), oxidative stress index (OSI), and urinary 8-isoprostane levels (a non-enzymatic peroxidation product of arachidonic acid) tend to increase after extended or continuous NSW, with concurrent decreases or alterations in total antioxidant capacity (TAC) and total antioxidant status (TAS), highlighting an imbalance in favor of oxidative damage 74,75,76,77

10.1111/wrr.13148 329 ZhouY.TangJ.LanJ.ZhangY.WangH.ChenQ.et al (2023)