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piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

For example, haemoglobin and myoglobin bind oxygen in the form of Fe 2 +, while catalase and peroxidase utilise Fe 3+ in redox reactions

ERK1/2 activation triggers important transcription factors

Yeast is a type of fungus