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NETs induced by nicotine negatively regulate autophagy in macrophages, resulting in the activation of inflammasome 63)

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The University of Kentuckys College of Agriculture provided Coresta Reference Tobacco Products: CRP1.1, CRP2.1, CRP3.1, and CRP4.1 as reference material for method validation

Consistent with the above, Results from animal experiments suggest that chronic nicotine exposure, whether through minipumps, intravenous self-administration, or other delivery methods, results in dependence characterized by withdrawal symptoms such as somatic signs, anxiety, and anhedonia, as indicated by an elevated reward threshold 19,20,21

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