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While agents like DFP and NAC demonstrate favorable BBB penetration, their systemic effects on iron metabolism raise concerns: iron chelators can induce unintended iron deficiency in peripheral tissues, while antioxidants may disrupt physiological redox balance, highlighting the need for brain-targeted delivery to minimize off-target effects

The effect of COX-2 on the apoptosis of intestinal epithelial cells (IECs) may be another key pathogenic factor in giardiasis

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