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While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including mitochondria where its concentration in the matrix equals that of the cytosol

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Oral isotretinoin may also be prescribed to individuals with milder forms of acne vulgaris if the condition is causing severe physical or emotional distress

It is not subject to feedback inhibition by glutathione (GSH) and its substrates gamma-glutamylcysteine (GGC) and glycine are rapidly ligated to form glutathione (GSH)