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Over- or underestimation of smoking can occur as a result of coverage bias related to sampling frames

They include the individuals age, genetic predisposition, and how long theyve smoked

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Check if the brand is MHRA-compliant (UKs Medicines and Healthcare products Regulatory Agency), provides lab test results, and uses pharmaceutical-grade ingredients

Concerning gastrointestinal involvement, its relevance in EDS and other HCTDs is well recognized [31, 69], whereas, until now, these issues were only slightly investigated in cEDS [106]