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Neuroprotective function of high glycolytic activity in astrocytes: common roles in stroke and neurodegenerative diseases

441 Lithium also regulates astrocytic morphology through the extracellular matrix regulatory enzyme lysyl oxidase (LOX) and peroxisome proliferator-activated receptor , with LOX being the most highly regulated lithium-responsive astroglial gene

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Lead, cadmium (from smoking) and arsenic disturb dopamine, this neurotransmitter gives the brain energy, motivation and the capacity for pleasure, when it becomes deficient you can get a low energy demotivated depression