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19shows almost complete protection of outer hair cells from cisplatin-induced degeneration in a cochlear explant model with 1.5 hour pretreatment followed by co-treatment with the otoprotectant 6-thioguanine with 10 M cisplatin.FIG

Modulation of nitric oxide (NO) pathways via the AkteNOS axis, improving blood flow, normalizing coagulation, and protecting vascular endothelium, including prevention and reversal of thrombosis in some animal models